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Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus

Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus

Aleksandra Łoczechin, Karin Séron, Alexandre Barras, Emerson Giovanelli, Sandrine Belouzard, Yen-Ting Chen, Nils Metzler-Nolte, Rabah Boukherroub, Jean Dubuisson, Sabine Szunerits

ACS Appl Mater Interfaces. 2019 Nov 20;11(46):42964-42974.

PMID: 31633330

Abstract:

Therapeutic options for the highly pathogenic human coronavirus (HCoV) infections are urgently needed. Anticoronavirus therapy is however challenging, as coronaviruses are biologically diverse and rapidly mutating. In this work, the antiviral activity of seven different carbon quantum dots (CQDs) for the treatment of human coronavirus HCoV-229E infections was investigated. The first generation of antiviral CQDs was derived from hydrothermal carbonization of ethylenediamine/citric acid as carbon precursors and postmodified with boronic acid ligands. These nanostructures showed a concentration-dependent virus inactivation with an estimated EC50 of 52 ± 8 μg mL-1. CQDs derived from 4-aminophenylboronic acid without any further modification resulted in the second-generation of anti-HCoV nanomaterials with an EC50 lowered to 5.2 ± 0.7 μg mL-1. The underlying mechanism of action of these CQDs was revealed to be inhibition of HCoV-229E entry that could be due to interaction of the functional groups of the CQDs with HCoV-229E entry receptors; surprisingly, an equally large inhibition activity was observed at the viral replication step.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS76106	Carbon quantum dots			Price

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