0

Functional Gene Variants of CYP3A4

A N Werk, I Cascorbi

Clin Pharmacol Ther. 2014 Sep;96(3):340-8.

PMID: 24926778

Abstract:

Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of more drugs in clinical use than any other foreign compound-metabolizing enzyme in humans. Recently, increasing evidence has been found showing that variants in the CYP3A4 gene have functional significance and--in rare cases--lead to loss of activity, implying tremendous consequences for patients. This review article highlights the functional consequences of all CYP3A4 variants recognized by the Human Cytochrome P450 (CYP) Allele Nomenclature Database.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR42412001 Cytochrome P450 3A5 human Cytochrome P450 3A5 human Price
qrcode