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Functionalization of PEGylated Fe3O4 Magnetic Nanoparticles With Tetraphosphonate Cavitand for Biomedical Application

Functionalization of PEGylated Fe3O4 Magnetic Nanoparticles With Tetraphosphonate Cavitand for Biomedical Application

C Tudisco, F Bertani, M T Cambria, F Sinatra, E Fantechi, C Innocenti, C Sangregorio, E Dalcanale, G G Condorelli

Nanoscale. 2013 Dec 7;5(23):11438-46.

PMID: 24056724

Abstract:

In this contribution, Fe3O4 magnetic nanoparticles (MNPs) have been functionalized with a tetraphosphonate cavitand receptor (Tiiii), capable of complexing N-monomethylated species with high selectivity, and polyethylene glycol (PEG) via click-chemistry. The grafting process is based on MNP pre-functionalization with a bifunctional phosphonic linker, 10-undecynylphosphonic acid, anchored on an iron surface through the phosphonic group. The Tiiii cavitand and the PEG modified with azide moieties have then been bonded to the resulting alkyne-functionalized MNPs through a "click" reaction. Each reaction step has been monitored by using X-ray photoelectron and FTIR spectroscopies. PEG and Tiiii functionalized MNPs have been able to load N-methyl ammonium salts such as the antitumor drug procarbazine hydrochloride and the neurotransmitter epinephrine hydrochloride and release them as free bases. In addition, the introduction of PEG moieties promoted biocompatibility of functionalized MNPs, thus allowing their use in biological environments.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1220675308	10-Undecynylphosphonic acid		1220675-30-8	Price

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