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Fungal Metabolites of (E)-guggulsterone and Their Antibacterial and Radical-Scavenging Activities

M Iqbal Choudhary, S Adnan Ali Shah, Amtul Sami, Asma Ajaz, Farzana Shaheen, Atta-ur-Rahman

Chem Biodivers. 2005 Apr;2(4):516-24.

PMID: 17192001

Abstract:

Fungal transformation of (E)-guggulsterone (= (17E)-pregna-4,17-diene-3,16-dione; 1) by Rhizopus stolonifer, Fusarium lini, Cunninghamella elegans, or Gibberella fujikuroi afforded ten hydroxylated metabolites (2-11; Scheme), which were fully characterized. Compounds 4-11 have not been described yet. Some of these novel hydroxylated metabolites, as well as acetylated derivatives thereof, exhibited significant antibacterial and radical-scavenging activities (Table 3).

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP39025246 (E)-Guggulsterone (E)-Guggulsterone 39025-24-6 Price
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