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Fungal Metabolites. Part 14. Novel Potent Immunosuppressants, Mycestericins, Produced by Mycelia Sterilia

S Sasaki, R Hashimoto, M Kiuchi, K Inoue, T Ikumoto, R Hirose, K Chiba, Y Hoshino, T Okumoto, T Fujita

J Antibiot (Tokyo). 1994 Apr;47(4):420-33.

PMID: 8195042

Abstract:

Mycestericins A, B, C, D and E were isolated from the culture broth of Mycelia sterilia ATCC 20349 along with thermozymocidin (= myriocin). Their structures were elucidated on the basis of spectroscopic studies and chemical evidence. The acetate of mycestericin C was identical with the acetate of 6,7-dihydromyriocin. Mycestericins suppressed the proliferation of lymphocytes in the mouse allogeneic mixed lymphocyte reaction, with a potency similar to that of myriocin.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP35891704-A Myriocin from Mycelia sterilia Myriocin from Mycelia sterilia 35891-70-4 Price
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