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Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum Verticillatum, Heracleum Sibiricum, Heracleum Angustisectum, and Heracleum Ternatum Extracts Against Enzymes Involved in Alzheimer's Disease and Type II Diabetes

Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum Verticillatum, Heracleum Sibiricum, Heracleum Angustisectum, and Heracleum Ternatum Extracts Against Enzymes Involved in Alzheimer's Disease and Type II Diabetes

Gulmira Ozek, Suleyman Yur, Fatih Goger, Temel Ozek, Boban Andjelkovic, Dejan Godjevac, Ivana Sofrenic, Ina Aneva, Milka Todorova, Antoaneta Trendafilova

Chem Biodivers. 2019 Apr;16(4):e1800672.

PMID: 30702800

Abstract:

Hexane extracts of Heracleum verticillatum, H. sibiricum, H. angustisectum, and H. ternatum were studied for their furanocoumarin content antioxidant potential and acetylcholinesterase and α-amylase inhibitory activities. Quantification of the furanocoumarins was performed by 1 H-NMR. Pimpinellin was found to be the main component in the roots of all studied species. Bergapten and imperatorin were the major compounds in the fruits of H. sibiricum and H. verticillatum, respectively, while byakangelicol dominated in H. angustisectum and H. ternatum fruits. The leaf and fruit extracts of H. angustisectum demonstrated the highest DPPH radical scavenging activity and TEAC (IC50 0.58 mg/mL and 1.83 mm, respectively). The root extracts of H. verticillatum and H. angustisectum were found to be the most effective against acetylcholinesterase (IC50 0.30 and 0.34 mg/mL, respectively). The studied extracts were not active or demonstrated a weak inhibitory effect (%Inh. up to 29.7) towards α-amylase.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP26091792	Byakangelicol		26091-79-2	Price

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