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Fusaric Acid Induces a Notochord Malformation in Zebrafish via Copper Chelation

Fusaric Acid Induces a Notochord Malformation in Zebrafish via Copper Chelation

Emily S Yin, Malika Rakhmankulova, Kaury Kucera, Jose Guedes de Sena Filho, Carolina E Portero, Alexandra Narváez-Trujillo, Scott A Holley, Scott A Strobel

Biometals. 2015 Aug;28(4):783-9.

PMID: 25913293

Abstract:

Over a thousand extracts were tested for phenotypic effects in developing zebrafish embryos to identify bioactive molecules produced by endophytic fungi. One extract isolated from Fusarium sp., a widely distributed fungal genus found in soil and often associated with plants, induced an undulated notochord in developing zebrafish embryos. The active compound was isolated and identified as fusaric acid. Previous literature has shown this phenotype to be associated with copper chelation from the active site of lysyl oxidase, but the ability of fusaric acid to bind copper ions has not been well described. Isothermal titration calorimetry revealed that fusaric acid is a modest copper chelator with a binding constant of 4.4 × 10(5) M(-1). These results shed light on the toxicity of fusaric acid and the potential teratogenic effects of consuming plants infected with Fusarium sp.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP536696	Fusaric acid		536-69-6	Price

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