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GABAA Receptor Subunit beta1 Is Involved in the Formation of Protease-Resistant Prion Protein in Prion-Infected Neuroblastoma Cells

GABAA Receptor Subunit beta1 Is Involved in the Formation of Protease-Resistant Prion Protein in Prion-Infected Neuroblastoma Cells

Tomohiro Kimura, Kensuke Ishikawa, Yuji Sakasegawa, Kenta Teruya, Tetsutaro Sata, Hermann Schätzl, Katsumi Doh-ura

FEBS Lett. 2010 Mar 19;584(6):1193-8.

PMID: 20159020

Abstract:

Gamma-aminobutyric acid type A (GABAA) receptor beta1 (gabrb1), a subunit of GABAA receptors involved in inhibitory effects on neurotransmission, was found to associate with the formation of protease-resistant prion protein in prion-infected neuroblastoma cells. Silencing of gabrb1 gene expression significantly decreased the abnormal prion protein level but paradoxically increased the normal prion protein level. Treatment with a gabrb1-specific inhibitor, salicylidene salicylhydrazide, dose-dependently decreased the abnormal prion protein level, but silencing of other GABAA receptor subunits' gene expression and treatments with the receptor antagonists and agonists did not. Therefore, gabrb1 involvement in abnormal prion protein formation is independent of GABAA receptors.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3232368	Salicylidene salicylhydrazide		3232-36-8	Price

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