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Garcinia Mangostana: A Source of Potential Anti-Cancer Lead Compounds Against CEM-SS Cell Line

Garcinia Mangostana: A Source of Potential Anti-Cancer Lead Compounds Against CEM-SS Cell Line

Gwendoline Cheng Lian Ee, Shaari Daud, Sheikh Ahmad Izzaddin, Mawardi Rahmani

J Asian Nat Prod Res. May-Jun 2008;10(5-6):475-9.

PMID: 18464091

Abstract:

Our current interest in searching for natural anti-cancer lead compounds from plants has led us to the discovery that the stem and roots of Garcinia mangostana can be a source of such compounds. The stem furnished 2,8-dihydroxy-6-methoxy-5-(3-methylbut-2-enyl)-xanthone (1), which is a new xanthone. Meanwhile, the root bark of the plant furnished six xanthones, namely alpha-mangostin (2), beta-mangostin (3), gamma-mangostin (4), garcinone D (5), mangostanol (6), and gartanin (7). The hexane and chloroform extracts of the root bark of G. mangostana as well as the hexane extract of the stem bark were found to be active against the CEM-SS cell line. gamma-Mangostin (4) showed good activity with a very low IC(50) value of 4.7 microg/ml, while alpha-mangostin (2), mangostanol (6), and garcinone D (5) showed significant activities with IC(50) values of 5.5, 9.6, and 3.2 microg/ml, respectively. This is the first report on the cytotoxicity of the extracts of the stem and root bark of G. mangostana and of alpha-mangostin, mangostanol, and garcinone D against the CEM-SS cell line.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP107390089	Garcinone D		107390-08-9	Price

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