Home
Resources
Publications
Garcinone D, a Natural Xanthone Promotes C17.2 Neural Stem Cell Proliferation: Possible Involvement of STAT3/Cyclin D1 Pathway and Nrf2/HO-1 Pathway

Garcinone D, a Natural Xanthone Promotes C17.2 Neural Stem Cell Proliferation: Possible Involvement of STAT3/Cyclin D1 Pathway and Nrf2/HO-1 Pathway

Xiaohong Yang, Shengnan Wang, Ying Ouyang, Yaling Tu, Anmin Liu, Yinghong Tian, Mingliang He, Rongbiao Pi

Neurosci Lett. 2016 Jul 28;626:6-12.

PMID: 27177723

Abstract:

Garcinia mangostana L. (Mangosteen) has been used to treat various pathological conditions, including inflammation and urinary tract infections. Here, we observed that garcinone D, a natural xanthone from mangosteen, promoted the proliferation of C17.2 neural progenitor cells and also resulted in a larger percentage of cells in S phase compared with the control group. Moreover, garcinone D increased the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) and Cyclin D1 in concentration- and time- dependent manners. Garcinone D also increased the protein levels of nuclear factor erythroid 2-related factor (Nrf2) and heme oxygenase-1 (HO-1) in concentration- and time- dependent manners, and inhibiting Nrf2 activation by brusatol could partly reverse garcinone D-induced C17.2 cell proliferation. Taken together, it is the first time to show that garcinone D promotes the proliferation of C17.2 neural stem cells, which may involve the STAT3/Cyclin D1 pathway and Nrf2/HO-1 pathway. It would provide new inspiration to develop garcinone D as a lead compound to promote the proliferation of endogenous neural stem cells (NSCs).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP107390089	Garcinone D		107390-08-9	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: