Home
Resources
Publications
Gene Expression Profiling of ErbB Receptors and Ligands in Human Meningiomas

Gene Expression Profiling of ErbB Receptors and Ligands in Human Meningiomas

Ingrid Laurendeau, Marcela Ferrer, Delia Garrido, Nicky D'Haene, Patricia Ciavarelli, Armando Basso, Michel Vidaud, Ivan Bieche, Isabelle Salmon, Irene Szijan

Cancer Invest. 2009 Jul;27(6):691-8.

PMID: 19440932

Abstract:

ErbB family receptors mediate major cellular functions implied in tumorigenesis, though their role in meningiomas was not thoroughly studied. Meningiomas represent 30% of primary cranial tumors, are mostly benign, and prevail in the second half of life. Tumor therapy requires information about molecular alterations, thus we studied expression of ErbB receptor and ligand genes by real-time RT-PCR in different meningioma grades. Receptors were overexpressed (ErbB1, ErbB2) or underexpressed (ErbB3, ErbB4). Ligands EGF, TGFA, AREG, DTR, BTD were underexpressed and the neuregulins were overexpressed or underexpressed. A strong ErbB1-ErbB2 correlation was found. These data might be useful for gene therapy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413236	Epigen (EPGN) human			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: