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Generation of Lipid Radicals in the Hippocampal Extracellular Space During Kainic Acid-Induced Seizures in Rats

Generation of Lipid Radicals in the Hippocampal Extracellular Space During Kainic Acid-Induced Seizures in Rats

Y Ueda, H Yokoyama, R Niwa, R Konaka, H Ohya-Nishiguchi, H Kamada

Epilepsy Res. 1997 Jan;26(2):329-33.

PMID: 9095394

Abstract:

We report direct electron spin resonance (ESR) evidence of extracellular free radical formation during kainic acid-induced seizures obtained using in vivo brain microdialysis in freely moving rats. Saline solution containing the spin trap agent alpha-(4-pyridyl-N-oxide)-N-tert-butylnitrone was perfused through the hippocampus. ESR analysis of the dialysate samples revealed a six-line spectra, for which the hyperfine coupling constants corresponded to those of the ESR signal from the lipoxygenase/linoleic acid system, a lipid radical generating system. This result is direct evidence that lipid peroxidation of the neuronal membrane progresses during seizure activity. Increased formation of lipid radicals may participate in the cascade of reactions leading to neuronal damage in the hippocampus following kainic acid-induced seizure activity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP66893810	α-(4-Pyridyl N-oxide)-N-tert-butylnitrone		66893-81-0	Price

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