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Genipin Inhibits LPS-Induced Inflammatory Response in BV2 Microglial Cells

Genipin Inhibits LPS-Induced Inflammatory Response in BV2 Microglial Cells

Jianjiao Wang, Liang Chen, Zuobin Liang, Yang Li, Fei Yuan, Jie Liu, Yu Tian, Zhen Hao, Fucheng Zhou, Xuanxi Liu, Yu Cao, Yongri Zheng, Qingsong Li

Neurochem Res. 2017 Oct;42(10):2769-2776.

PMID: 28497344

Abstract:

Genipin, an aglycon of geniposide, has been reported to have anti-inflammatory effect. However, the anti-inflammatory activity of genipin on LPS-stimulated BV2 microglial cells has not been reported. In this study, we investigated the molecular mechanisms responsible for the anti-inflammatory activity of genipin both in vivo and in vitro. The levels of TNF-α, IL-1β, NO and PGE2 were detected by ELISA. The expression of Nrf2, HO-1, and NF-κB were detected by western blot analysis. In vivo, genipin significantly attenuated LPS-induced memory deficit in the Morris water maze and passive avoidance tasks. Genipin also inhibited LPS-induced TNF-α and IL-1β expression in brain tissues. In vitro, our results showed that genipin inhibited LPS-induced TNF-α, IL-1β, NO and PGE2 production in a concentration-dependent manner. Genipin also suppressed LPS-induced NF-κB activation. In addition, the expression of Nrf2 and HO-1 were up-regulated by treatment of genipin. Furthermore, the inhibition of genipin on inflammatory mediator production was attenuated by transfection with Nrf2 siRNA. In conclusion, genipin inhibited LPS-induced inflammatory response by activating Nrf2 signaling pathway in BV2 microglia.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP6902778	Genipin		6902-77-8	Price

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