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Geniposidic Acid Protects Against D-galactosamine and Lipopolysaccharide-Induced Hepatic Failure in Mice

Geniposidic Acid Protects Against D-galactosamine and Lipopolysaccharide-Induced Hepatic Failure in Mice

So-Jin Kim, Kang-Min Kim, Juhyun Park, Jong-Hwan Kwak, Yeong Shik Kim, Sun-Mee Lee

J Ethnopharmacol. 2013 Mar 7;146(1):271-7.

PMID: 23298456

Abstract:

Ethnopharmacological relevance:
Geniposidic acid (GA) is an iridoid glucoside isolated from Gardeniae jasminoides Ellis (Rubiaceae) that has long been used to treat inflammation, jaundice and hepatic disorders.
Aims of the study:
This study examined the cytoprotective properties of GA against D-galactosamine (GalN)/lipopolysaccharide (LPS)-induced fulminant hepatic failure.
Materials and methods:
Mice were given an intraperitoneal injection of GA (12.5, 25, 50 mg/kg) 1h before receiving GalN (800 mg/kg)/LPS (40 μg/kg). Liver and blood samples were collected 1 and 8 h after GalN/LPS injection.
Results:
The survival rate of the GA group was significantly higher than the control. GalN/LPS increased serum aminotransferase activity, serum tumor necrosis factor-α level and hepatic lipid peroxidation and decreased hepatic glutathione content. These changes were attenuated by GA. GA augmented increases in serum interleukin-6 level, heme oxygenase-1 and NF-E2-related factor 2 protein expression. Mice treated with GA decreased cleaved caspase-8 and caspase-3 protein expression and showed significantly fewer apoptotic cells. GA increased Bcl-xL protein expression and decreased Bax protein expression. Moreover, GA treatment enhanced phosphorylation of signal transducer and activator of transcription 3.
Conclusion:
Our findings suggest that geniposidic acid alleviates GalN/LPS-induced liver injury by enhancing antioxidative defense system and reducing apoptotic signaling pathways.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP27741011	Geniposidic acid		27741-01-1	Price

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