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Genotoxic Assessment of Carbon Nanotubes

Olivera Nešković, Gordana Joksić, Ana Valenta-Šobot, Jelena Cvetićanin, Djordje Trpkov, Andreja Leskovac, Sandra Petrović

Methods Mol Biol. 2013;991:315-23.

PMID: 23546681

Abstract:

Carbon nanotubes are unique one-dimensional macromolecules with promising application in biology and medicine. Since their toxicity is still under debate, here we describe an investigation of genotoxic properties of purified single-walled carbon nanotubes (SWCNT), multiwall carbon nanotubes (MWCNT), and amide-functionalized purified SWCNT. We used two different cell systems: cultured human lymphocytes where we employed cytokinesis-block micronucleus test and human fibroblasts where we investigate the induction of DNA double-strand breaks (DSBs) employing H2AX phosphorylation assay.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
LS71709 Carbon nanotube, single-walled, amide functionalized Carbon nanotube, single-walled, amide functionalized Price
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