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Geranylgeraniol-induced Myogenic Differentiation of C2C12 Cells

Geranylgeraniol-induced Myogenic Differentiation of C2C12 Cells

Takuma Matsubara, Mariko Urata, Tsuyoshi Nakajima, Mari Fukuzaki, Ryo Masuda, Yoshiyuki Yoshimoto, William N Addison, Chihiro Nakatomi, Kazmasa Morikawa, Min Zhang, Katsura Saeki, Yukiko Takahashi, Atsuko Nakamichi, etc.

In Vivo. Nov-Dec 2018;32(6):1427-1431.

PMID: 30348697

Abstract:

Background:
Geranylgeraniol (GGOH) is a C20 isoprenoid found in fruits, vegetables, and grains, including rice. As a food substance, GGOH is categorized as 'Generally Recognized as Safe'. GGOH is an intermediate product in the mevalonate pathway and acts as a precursor to geranylgeranyl pyrophosphate.
Materials and methods:
C2C12 mouse myoblasts derived from muscle satellite cells were used. Quantitative reverse-transcriptase polymerase chain reaction, western blotting analysis, and immunocytochemical analysis were performed to respectively assess mRNA expression, protein levels, and the number of myofibers.
Results:
GGOH reduced the expression levels of skeletal muscle atrophy-related ubiquitin ligases in myofibers derived from C2C12 cells. GGOH induced myogenic differentiation of C2C12 cells via geranylgeranylation. GGOH did not adversely affect the proliferation of C2C12 cells.
Conclusion:
GGOH induces myoblast differentiation in C2C12 cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP24034739	Geranylgeraniol		24034-73-9	Price

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