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GF 109203X, a Selective Inhibitor of Protein Kinase C, Impairs Retention Performance in an Operant Task

GF 109203X, a Selective Inhibitor of Protein Kinase C, Impairs Retention Performance in an Operant Task

J Stemmelin, C Mathis, A Ungerer

Neuroreport. 1999 Sep 9;10(13):2805-9.

PMID: 10511444

Abstract:

The effects of post-training administration of GF 109203X (5 and 50 ng i.c.v.), a selective inhibitor of protein kinase C, on retention performance were investigated in a positively reinforced lever press task, in male Swiss mice. Both doses of GF 109203X suppressed the spontaneous improvement of performance observed in control animals between the last 5 min of the acquisition session and the first 5 min of the retention session 24 h later. GF 109203X had no effect on food intake and locomotor activity. These data suggest that GF 109203X selectively interferes with mechanisms underlying post-training organization of information and that protein kinase C is involved in this memory process.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP133052901-A	GF 109203X		133052-90-1	Price

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