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Ginsenoside Rb3 Exerts Protective Properties Against Cigarette Smoke Extract-Induced Cell Injury by Inhibiting the p38 MAPK/NF-κB and TGF-β1/VEGF Pathways in Fibroblasts and Epithelial Cells

Ginsenoside Rb3 Exerts Protective Properties Against Cigarette Smoke Extract-Induced Cell Injury by Inhibiting the p38 MAPK/NF-κB and TGF-β1/VEGF Pathways in Fibroblasts and Epithelial Cells

Manying Wang, Xuenan Chen, Wenqi Jin, Xiaohao Xu, Xiangyan Li, Liwei Sun

Biomed Pharmacother. 2018 Dec;108:1751-1758.

PMID: 30372878

Abstract:

Cigarette smoke causes many adverse effects such as inflammation, oxidative stress, and excessive accumulation of the extracellular matrix (ECM). Ginsenoside Rb3 has anti-inflammatory and anti-oxidative effects, which may contribute to delaying the injury caused by cigarette smoke. In this study, we used cigarette smoke extract (CSE) to establish cell injury models in WI-38 human fetal lung fibroblasts and 16HBE human bronchial epithelial cells. Our results showed that Rb3 protected against CSE-induced cytotoxicity in both cell lines. In addition, it significantly inhibited the secretion of inflammatory factors, such as interleukin-8 and tumor necrosis factor alpha, by inhibiting the phosphorylation of p38 mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB). Moreover, Rb3 pre-treatment led to an increase in the levels of glutathione (GSH) and activities of superoxide dismutase, glutathione peroxidase (GSH-Px), and catalase to reduce the oxidative stress induced by CSE. Additionally, Rb3 decreased the levels of ECM proteins including collagen I (Col I), Col III, and elastin after CSE treatment by inhibiting the expression of transforming growth factor beta 1 (TGF-β1)-induced vascular endothelial growth factor (VEGF). Our findings suggest that Rb3 prevented CSE-induced inflammation and oxidative stress as well as the excessive accumulation of ECM in WI-38 and 16HBE cells to protect against cell injury by inhibiting the p38 MAPK/NF-κB and TGF-β1/VEGF pathways. The results of this study may be valuable for the development of Rb3 to combat the damage caused by cigarette smoke.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP68406268	Ginsenoside Rb3		68406-26-8	Price

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