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Ginsenoside Rh1: A Systematic Review of Its Pharmacological Properties

Ginsenoside Rh1: A Systematic Review of Its Pharmacological Properties

Dao Ngoc Hien Tam, Duy Hieu Truong, Thi Thanh Hoa Nguyen, Le Nhat Quynh, Linh Tran, Hong Duong Nguyen, Bahaa Eldin Shamandy, Thi Minh Huong Le, Dang Khoa Tran, Dina Sayed, Van Vinh Vu, Shusaku Mizukami, etc.

Planta Med. 2018 Feb;84(3):139-152.

PMID: 29329463

Abstract:

Ginsenoside Rh1 is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. The objective of this study was to review the pharmacological effects of ginsenoside Rh1 in a systematic manner. We performed searches on eight electronic databases including MEDLINE (Pubmed), Scopus, Google Scholar, POPLINE, Global Health Library, Virtual Health Library, the System for Information on Grey Literature in Europe, and the New York Academy of Medicine Grey Literature Report to select the original research publications reporting the biological and pharmacological effects of ginsenoside Rh1 from in vitro and in vivo studies regardless of publication language and study design. Upon applying the inclusion and exclusion criteria, we included a total of 57 studies for our systemic review. Ginsenoside Rh1 exhibited the potent characteristics of anti-inflammatory, antioxidant, immunomodulatory effects, and positive effects on the nervous system. The cytotoxic effects of ginsenoside Rh1 were dependent on different types of cell lines. Other pharmacological effects including estrogenic, enzymatic, anti-microorganism activities, and cardiovascular effects have been mentioned, but the results were considerably diverged. A higher quality of evidence on clinical trial studies is highly recommended to confirm the consistent efficacy of ginsenoside Rh1.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP63223869	Ginsenoside Rh1		63223-86-9	Price

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