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Ginsenoside Rh2 Inhibits Migration of Lung Cancer Cells Under Hypoxia

Ginsenoside Rh2 Inhibits Migration of Lung Cancer Cells Under Hypoxia

Yingying Chen, Yuqiang Zhang, Wei Song, Ying Zhang, Xiu Dong, Mingqi Tan

Anticancer Agents Med Chem. 2019;19(13):1633-1641.

PMID: 31272362

Abstract:

Background:
Ginsenoside Rh2 (Rh2), which is extracted from ginseng, exerts antitumor activity. Here we would like to study the role of Rh2 on hypoxia-induced migration in lung adenocarcinoma.
Methods:
Lung adenocarcinoma A549 and H1299 cells were cultured in 1% O2 condition to mimic the hypoxic tumor microenvironment. The migrations of cancer cells were measured by transwell assay and scratch assay.
Results:
Rh2 could inhibit hypoxia-induced A549 and H1299 cell migration via increase of mir-491 expression. Further, mir-491 antisense oligonucleotide could repress hypoxia-induced migration and the expression of matrix metalloproteinase (MMP)-9 expression in Rh2-treated A549 cells.
Conclusion:
These findings suggest that Rh2 exerts anti-metastasis activity in the hypoxic tumor microenvironment in lung adenocarcinoma cells via mir-491.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP78214332	Ginsenoside Rh2		78214-33-2	Price

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