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Glucose-sensitivity of Liposomes Incorporating Conjugates of Glucose Oxidase and poly(N-isopropylacrylamide-co-methacrylic Acid-Co-Octadecylacrylate)

Glucose-sensitivity of Liposomes Incorporating Conjugates of Glucose Oxidase and poly(N-isopropylacrylamide-co-methacrylic Acid-Co-Octadecylacrylate)

Seong-Min Jo, Hyeon Yong Lee, Jin-Chul Kim

Int J Biol Macromol. 2009 Nov 1;45(4):421-6.

PMID: 19549540

Abstract:

Liposomes, which release their contents in response to the concentration of glucose, were prepared by modifying the liposomal surface with the conjugate of poly(N-isopropylacrylamide-co-methacrylic acid-co-octadecylacrylate) (P(NIPAM-co-MAA-co-ODA)) and glucose oxidase (GOD). The maximum enzymatic activity of copolymer conjugated GOD (Polym-GOD) was observed around pH 5.0 and the value was about 40% of that of native GOD. Nine lysine residues per GOD molecule, on average, were found to be covalently attached to the copolymers. Egg phosphatidylcholine liposomes bearing Polym-GOD released their contents in response to the concentration of glucose and the sensitivity was higher than dipalmitoylphosphatidylcholine liposomes.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP151954971	Poly(N-isopropylacrylamide-co-methacrylic acid)		151954-97-1	Price
LS74659	Poly(N-isopropylacrylamide-co-methacrylic acid-co-octadecyl acrylate)			Price

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