Home
Resources
Publications
α-Glucosyl Hesperidin Induced an Improvement in the Bioavailability of Pranlukast Hemihydrate Using High-Pressure Homogenization

α-Glucosyl Hesperidin Induced an Improvement in the Bioavailability of Pranlukast Hemihydrate Using High-Pressure Homogenization

Hiromasa Uchiyama, Yuichi Tozuka, Fusatoshi Asamoto, Hirofumi Takeuchi

Int J Pharm. 2011 May 30;410(1-2):114-7.

PMID: 21419200

Abstract:

The α-glucosyl hesperidin (Hsp-G)-induced improvement of both the dissolution and absorption properties of pranlukast hemihydrate (PLH) was achieved by means of a high-pressure homogenization (HPH) processing. The average particle size in the HPH-processed suspension was decreased significantly after 50 cycles of processing and reached a constant size of ca. 300 nm. The amount of dissolved PLH gradually increased with the pass number of HPH processing, and was extremely higher than the PLH solubility (0.8 μg/mL at 37°C) after the HPH processing. On a dissolution study of the freeze-dried sample of HPH-processed PLH/Hsp-G (1/10), the apparent solubility of PLH was at least 2.5-fold more than that of untreated PLH crystals. The transport study showed that the amount of PLH that had permeated through the Caco-2 cell monolayers was improved in the case of HPH-processed PLH/Hsp-G (1/10). The bioavailability of PLH from HPH-processed PLH/Hsp-G (1/10) showed a 3.9- and 2.2-fold improvement over the PLH crystal in terms of C(max) and AUC values, respectively. Hsp-G formed an associated structure in aqueous media. High-pressure homogenization provides a good opportunity for molecular-level interaction of PLH and the associated structure of Hsp-G to occur. The use of Hsp-G under HPH processing was a promising way to enhance the dissolution and absorption of PLH without using an organic solvent.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP150821037	Pranlukast hemihydrate		150821-03-7	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: