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Glucosyltransferase Capable of Catalyzing the Last Step in Neoandrographolide Biosynthesis

Yuan Li, Hui-Xin Lin, Jian Wang, Jian Yang, Chang-Jiang-Sheng Lai, Xing Wang, Bao-Wei Ma, Jin-Fu Tang, Yong Li, Xin-Lin Li, Juan Guo, Wei Gao, Lu-Qi Huang

Org Lett. 2018 Oct 5;20(19):5999-6002.

PMID: 30234309

Abstract:

ApUGT, a diterpene glycosyltransferase from Andrographis paniculata, could transfer a glucose to the C-19 hydroxyl moiety of andrograpanin to form neoandrographolide. This glycosyltransferase has a broad substrate scope, and it can glycosylate 26 natural and unnatural compounds of different structural types. This study provides a basis for exploring the glycosylation mechanism of ent-labdane-type diterpenes and plays an important role in diversifying the structures used in drug discovery.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP27215141 Neoandrographolide Neoandrographolide 27215-14-1 Price
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