Home
Resources
Publications
Glutamine Metabolism in Cancer: Understanding the Heterogeneity

Glutamine Metabolism in Cancer: Understanding the Heterogeneity

Ahmad A Cluntun, Michael J Lukey, Richard A Cerione, Jason W Locasale

Trends Cancer. 2017 Mar;3(3):169-180.

PMID: 28393116

Abstract:

Reliance on glutamine has long been considered a hallmark of cancer cell metabolism. However, some recent studies have challenged this notion in vivo, prompting a need for further clarifications on the role of glutamine metabolism in cancer. We find that there is ample evidence of an essential role for glutamine in tumors and that a variety of factors, including tissue type, the underlying cancer genetics, the tumor microenvironment and other variables such as diet and host physiology collectively influence the role of glutamine in cancer. Thus the requirements for glutamine in cancer are overall highly heterogeneous. In this review, we discuss the implications both for basic science and for targeting glutamine metabolism in cancer therapy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP56859-B	Glutamine		56-85-9	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: