Home
Resources
Publications
Glutathione as a Photo-Stabilizer of Avobenzone: An Evaluation Under Glass-Filtered Sunlight Using UV-spectroscopy

Glutathione as a Photo-Stabilizer of Avobenzone: An Evaluation Under Glass-Filtered Sunlight Using UV-spectroscopy

Panchada Ch V Govindu, Basavaprabhu Hosamani, Smriti Moi, Dhananjeyan Venkatachalam, Sabreddy Asha, Varun N John, V Sandeep, Konkallu Hanumae Gowd

Photochem Photobiol Sci. 2019 Jan 1;18(1):198-207.

PMID: 30421772

Abstract:

Avobenzone is the most widely used UVA filter in sunscreen lotion and it is prone to degradation in the presence of sunlight/UV radiation. To overcome the photo-instability of avobenzone, various photostabilizers have been used as additives, including antioxidants such as vitamin C, vitamin E, and ubiquinone. In the present study, the well known antioxidant, glutathione, was evaluated for protecting avobenzone from photodegradation in the presence of glass-filtered sunlight. The features of glutathione as a skin whitener and a radical scavenger in cells have prompted the assessment of the photostabilzing activity of glutathione on avobenzone. Glutathione significantly attenuated the glass-filtered sunlight-induced degradation of avobenzone at equimolar or higher ratios of glutathione and avobenzone. Mutational studies have been undertaken to investigate the role of the thiol group and the isopeptide bond of glutathione on its photoprotection activity towards avobenzone. The thiol group of glutathione plays a vital role in exhibiting the photoprotection activity, which was further supported by the studies on photodegradation of avobonzone in the presence of β-mercaptoethanol. The dual role of glutathione as a skin whitening agent and a photostabilizer of avobenzone may be useful for the development of multipurpose cosmetic lotions.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP70356091-A	Avobenzone		70356-09-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: