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Gly-Pro-Glu Protects Beta-Amyloid-Induced Somatostatin Depletion in the Rat Cortex

Gly-Pro-Glu Protects Beta-Amyloid-Induced Somatostatin Depletion in the Rat Cortex

David Aguado-Llera, Mercedes Martín-Martínez, María Teresa García-López, Eduardo Arilla-Ferreiro, Vicente Barrios

Neuroreport. 2004 Aug 26;15(12):1979-82.

PMID: 15305149

Abstract:

The effect of Gly-Pro-Glu (GPE) on the somatostatinergic system of the temporal cortex in amyloid beta-peptide (Abeta) treated rats was investigated. Intracerebroventricular Abeta25-35 administration for 14 days (300 pmol/day) to ovariectomized rats produced a marked reduction in somatostatin (SRIF) content, SRIF receptor density and reduced the inhibitory effect of SRIF on adenylyl cyclase activity. I.p. injection of three doses (300 microg) of GPE on days 0, 6 and 12 resulted in a partial recovery of the parameters affected by Abeta25-35 administration. These results indicate that GPE may have an in vivo effect protecting the temporal cortical somatostatinergic system from Abeta insult.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP32302764	Gly-Pro-Glu		32302-76-4	Price

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