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Glycogen Phosphorylase a Inhibitors With a Phenethylphenylphthalimide Skeleton Derived From Thalidomide-Related Alpha-Glucosidase Inhibitors and Liver X Receptor Antagonists

Kazunori Motoshima, Minoru Ishikawa, Kazuyuki Sugita, Yuichi Hashimoto

Biol Pharm Bull. 2009 Sep;32(9):1618-20.

PMID: 19721243

Abstract:

Novel glycogen phosphorylase a (GPa) inhibitors with a phenethylphenylphthalimide skeleton were prepared based on alpha-glucosidase inhibitors and liver X receptor (LXR) antagonists derived from thalidomide. Their structure-activity relationships were analyzed. Some of the compounds thus prepared showed potent inhibitory activity against rabbit muscle GPa with more than 10-fold greater efficacy than a typical GPa inhibitor, 1,4-dideoxy-1,4-imino-D-arabinitol.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP9032104 Phosphorylase a from rabbit muscle Phosphorylase a from rabbit muscle 9032-10-4 Price
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