Home
Resources
Publications
Glycosylated Diphyllin as a Broad-Spectrum Antiviral Agent Against Zika Virus

Glycosylated Diphyllin as a Broad-Spectrum Antiviral Agent Against Zika Virus

Alicia Martinez-Lopez, Mirjana Persaud, Maritza Puray Chavez, Hongjie Zhang, Lijun Rong, Shufeng Liu, Tony T Wang, Stefan G Sarafianos, Felipe Diaz-Griffero

EBioMedicine. 2019 Sep;47:269-283.

PMID: 31501074

Abstract:

Background:
Flaviviruses such as Zika cause sporadic pandemic outbreaks worldwide. There is an urgent need for anti-Zika virus (ZIKV) drugs to prevent mother-to-child transmission of ZIKV, new infections in high-risk populations, and the infection of medical personnel in ZIKV-affected areas.
Methods:
Here, we showed that the small molecule 6-deoxyglucose-diphyllin (DGP) exhibited anti-ZIKV activity both in vitro and in vivo. DGP potently blocked ZIKV infection across all human and monkey cell lines tested. DGP also displayed broad-spectrum antiviral activity against other flaviviruses. Remarkably, DGP prevented ZIKV-induced mortality in mice lacking the type I interferon receptor (Ifnar1-/-). Cellular and virological experiments showed that DGP blocked ZIKV at a pre-fusion step or during fusion, which prevented the delivery of viral contents into the cytosol of the target cell. Mechanistic studies revealed that DGP prevented the acidification of endosomal/lysosomal compartments in target cells, thus inhibiting ZIKV fusion with cellular membranes and infection.
Findings:
These investigations revealed that DGP inhibits ZIKV infection in vitro and in vivo.
Interpretation:
The small molecule DGP has great potential for preclinical studies and the ability to inhibit ZIKV infection in humans.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP22055227	Diphyllin		22055-22-7	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: