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Glycyl-L-glutamine Antagonizes alpha-MSH-elicited Thermogenesis

Glycyl-L-glutamine Antagonizes alpha-MSH-elicited Thermogenesis

G E Resch, W R Millington

Peptides. Sep-Oct 1993;14(5):971-5.

PMID: 8284272

Abstract:

The objective of this study was to determine whether glycyl-L-glutamine [beta-endorphin(30-31)] modulates the thermoregulatory actions of alpha-MSH. Microinjection of alpha-MSH (0.06 nmol) into PGE2-responsive thermogenic sites in the medial preoptic area of rats generated a hyperthermic response, inducing a 0.85 +/- 0.19 degrees C rise in colonic temperature (Tc) within 45 min. Coadministration of glycyl-L-glutamine (3.0 nmol) completely blocked the response, maintaining Tc at baseline levels. This was not attributable to glycyl-L-glutamine hydrolysis because coadministration of glycine and glutamine had no effect on alpha-MSH-induced thermogenesis. Glycyl-L-glutamine, injected alone, was similarly without effect. These data indicate that glycyl-L-glutamine inhibits alpha-MSH-induced thermogenesis but is devoid of thermoregulatory activity itself.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP211446467	Glycyl-L-glutamine		211446-46-7	Price

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