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Glycyl-L-glutamine [beta-endorphin-(30-31)] Attenuates Hemorrhagic Hypotension in Conscious Rats

Glycyl-L-glutamine [beta-endorphin-(30-31)] Attenuates Hemorrhagic Hypotension in Conscious Rats

M D Owen, S Gürün, G P Zaloga, W R Millington

Am J Physiol. 1997 Nov;273(5):R1598-606.

PMID: 9374799

Abstract:

The profound hypotension caused by acute hemorrhage is thought to involve opioid peptide neurons. In this study, we tested whether glycyl-L-glutamine [Gly-Gln; beta-endorphin-(30-31)], a nonopioid peptide derived from beta-endorphin processing, prevents the cardiovascular depression induced by hemorrhage in conscious and anesthetized rats. Previously, we found that Gly-Gln inhibits the hypotension and respiratory depression produced by beta-endorphin and morphine but does not affect opioid antinociception. Hemorrhage (2.5 ml/100 g body wt over 20 min) lowered arterial pressure in conscious rats (from 120.1 +/- 2.9 to 56.2 +/- 4.7 mmHg) but did not change heart rate significantly. Intracerebroventricular Gly-Gln (3, 10, or 30 nmol) pretreatment inhibited the fall in arterial pressure and increased heart rate significantly. The response was dose related and was sustained during the 35-min posthemorrhage interval. Pentobarbital sodium anesthesia potentiated the hemodynamic response to hemorrhage and attenuated the effect of Gly-Gln. Gly-Gln (10 or 100 nmol icv) did not influence arterial pressure or heart rate in normotensive rats. These data indicate that Gly-Gln is an effective antagonist of hemorrhagic hypotension.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP211446467	Glycyl-L-glutamine		211446-46-7	Price

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