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Glycyl-L-glutamine-enriched Total Parenteral Nutrition Maintains Small Intestine Gut-Associated Lymphoid Tissue and Upper Respiratory Tract Immunity

Glycyl-L-glutamine-enriched Total Parenteral Nutrition Maintains Small Intestine Gut-Associated Lymphoid Tissue and Upper Respiratory Tract Immunity

J Li, B K King, P G Janu, K B Renegar, K A Kudsk

JPEN J Parenter Enteral Nutr. Jan-Feb 1998;22(1):31-6.

PMID: 9437652

Abstract:

Background:
i.v. administration of a total parenteral nutrition (TPN) solution results in small intestinal gut-associated lymphoid tissue (GALT) atrophy, lowers small intestinal immunoglobulin A (IgA) levels, and impairs upper respiratory tract secretory IgA-mediated mucosal immunity; isonitrogenous supplementation of TPN with 2% glutamine attenuates these changes. This experiment examines whether a 2% glycyl-L-glutamine-enriched TPN solution reverses i.v. TPN-induced changes as effectively as L-glutamine.
Methods:
Male Institute of Cancer Research (ICR) mice underwent intranasal inoculation with H1N1 influenza virus to establish immunity. After 3 weeks, mice were randomized to chow, i.v. feeding of a TPN solution, glutamine-enriched TPN, or glycyl-L-glutamine-enriched TPN. After 4 days of feeding, mice were challenged intranasally with influenza virus and killed at 40 hours to determine viral shedding from the respiratory tract; normal convalescent mice do not shed virus because they possess intact IgA-mediated mechanisms Lymphocytes were isolated from Peyer's patches, the intraepithelial layer, and lamina propria to determine cell yields.
Results:
Total lymphocyte yield in the Peyer's patches, the intraepithelial layer, and lamina propria decreased with TPN but remained normal with glutamine and glycyl-L-glutamine. Upon challenge, 70% of the mice in the TPN group shed virus in nasal secretions, whereas only 20% of the glutamine-treated group, 18% of glycyl-L-glutamine group and none of the Chow group were virus positive.
Conclusions:
L-Glutamine and glycyl-L-glutamine have similar effects on i.v. administered TPN-associated (GALT) atrophy and decreased upper respiratory tract immunity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP211446467	Glycyl-L-glutamine		211446-46-7	Price

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