Home
Resources
Publications
Gold/WS 2 nanocomposites fabricated by in-situ ultrasonication and assembling for photoelectrochemical immunosensing of carcinoembryonic antigen

Gold/WS 2 nanocomposites fabricated by in-situ ultrasonication and assembling for photoelectrochemical immunosensing of carcinoembryonic antigen

Ye Hu, Yajiao Huang, Zhengguo Wang, Yanying Wang, Xiaoxue Ye, WingLeung Wong, Chunya Li, Dong Sun

Mikrochim Acta. 2018 Dec 1;185(12):570.

PMID: 30506429

Abstract:

Tungsten disulfide (WS2) nanosheets were obtained by exfoliating WS2 bulk crystals in N-methylpyrrolidone by ultrasonication. Gold nanoparticles (GNPs) were synthesized by in-situ ultrasonication of sodium citrate and HAuCl4 while fabricating the WS2 nanosheets. In this way, the GNPs were self-assembled on WS2 nanosheets to form a GNPs/WS2 nanocomposite through interaction between sulfur and gold atoms. The photoelectrochemical response of WS2 nanosheets is significantly enhanced after integration of the GNPs. The GNPs/WS2 nanocomposite was coated onto a glassy carbon electrode (GCE) to construct a sensing interface which then was modified with an antibody against the carcinoembryonic antigen (CEA) to obtain a photoelectrochemical immunosensor for CEA. Under optimized conditions, the decline in relative photocurrent is linearly related to the logarithm of the CEA concentration in the range from 0.001 to 40 ng mL-1. The detection limit is 0.5 pg mL-1 (at S/N = 3). The assay is sensitive, selective, stable and reproducible. It was applied to the determination of CEA in clinical serum samples. Graphical abstract Schematic presentation of the fabrication of Au/WS2 nanocomposites by in-situ ultrasonication and the procedure for the CEA photoelectrochemical immunosensor preparation, and the photocurrent response towards the carcinoembryonic antigen.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42184	Anions - WS			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: