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Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand

Raysa Khan, Graham Marsh, Robert Felix, Paul D Kemmitt, Matthias G J Baud, Alessio Ciulli, John Spencer

ACS Omega. 2017 Aug 8;2(8):4328-4332.

PMID: 31457724

Abstract:

TC AC 28, 6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester, has been synthesized on a near-gram scale in seven steps with notable improvements in the reported poor-yielding last two steps enabling this key chemical probe compound to be available for researchers.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR42416127 BET Bromodomain Ligand BET Bromodomain Ligand Price
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