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Granulocyte Aggregation Is Edetic Acid and Temperature Dependent

Granulocyte Aggregation Is Edetic Acid and Temperature Dependent

N Bizzaro

Arch Pathol Lab Med. 1993 May;117(5):528-30.

PMID: 8489344

Abstract:

Nineteen cases of leukocyte agglutination were observed in the last 6 years, while performing routine blood cell counts with an autoanalyzer (Technicon H6000). The phenomenon occurred only in edetic acid-anticoagulated samples and only at room temperature. Leukocyte aggregation could be reproduced by incubating patient serum samples or edetic acid-plasma with whole blood from ABO-compatible healthy control subjects. When patient serum samples or plasma samples were first preincubated with anti-IgM serum and then mixed with normal blood, leuko-agglutinates were not observed, suggesting that a plasma factor, probably an IgM, was responsible for the phenomenon. Nonetheless, IgM presence could not be correlated with any particular disease or the use of specific drugs.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP60004	Edetic acid		60-00-4	Price

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