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Granulocyte-colony Stimulating Factor: A New Player for the Enteric Nervous System

Granulocyte-colony Stimulating Factor: A New Player for the Enteric Nervous System

Anne Schuster, Markus Klotz, Tanja Schwab, Rainer Lilischkis, Armin Schneider, Karl-Herbert Schäfer

Cell Tissue Res. 2014 Jan;355(1):35-48.

PMID: 24253464

Abstract:

The enteric nervous system (ENS) controls and modulates gut motility and responds to food intake and to internal and external stimuli such as toxins or inflammation. Its plasticity is maintained throughout life by neural progenitor cells within the enteric stem cell niche. Granulocyte-colony stimulating factor (G-CSF) is known to act not only on cells of the immune system but also on neurons and neural progenitors in the central nervous system (CNS). Here, we demonstrate, for the first time, that G-CSF receptor is present on enteric neurons and progenitors and that G-CSF plays a role in the expansion and differentiation of enteric neural progenitor cells. Cultured mouse ENS-neurospheres show increased expansion with increased G-CSF concentrations, in contrast to CNS-derived spheres. In cultures from differentiated ENS- and CNS-neurospheres, neurite outgrowth density is enhanced depending on the amount of G-CSF in the culture. G-CSF might be an important factor in the regeneration and differentiation of the ENS and might be a useful tool for the investigation and treatment of ENS disorders.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248593	Granulocyte Colony-Stimulating Factor from mouse			Price

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