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Green Light-Emitting Diode Phototherapy for Neonatal Hyperbilirubinemia: Randomized Controlled Trial

Green Light-Emitting Diode Phototherapy for Neonatal Hyperbilirubinemia: Randomized Controlled Trial

Toru Kuboi, Takashi Kusaka, Hitoshi Okada, Makoto Arioka, Kohichiroh Nii, Megumi Takahashi, Satoshi Yamato, Takaaki Sadamura, Wataru Jinnai, Akiko Nakano, Susumu Itoh

Pediatr Int. 2019 May;61(5):465-470.

PMID: 30838731

Abstract:

Background:
The main photochemical pathway in phototherapy for neonatal hyperbilirubinemia is the production and elimination (in bile or urine) of cyclobilirubin, which is a structural photoisomer of bilirubin, and which is most efficiently produced by green light. Green light-emitting diode (LED) phototherapy, however, has not been evaluated in the clinical setting because it is not recommended in American Academy of Pediatrics guidelines. We therefore compared the efficacy of green LED phototherapy and blue LED phototherapy in patients with neonatal hyperbilirubinemia.
Methods:
In this prospective randomized controlled trial, neonates with hyperbilirubinemia were randomly allocated to a green LED or blue LED phototherapy group. Both groups underwent 24 h of phototherapy, and blood was sampled before and after 24 h of phototherapy. Total serum bilirubin (TSB) was measured using enzymatic methods and bilirubin photoisomers were measured on high-performance liquid chromatography.
Results:
Thirty-four infants were randomized (green, n = 16; blue, n = 18). TSB decreased significantly from 15.3 ± 1.5 to 13.9 ± 1.5 mg/dL in the green LED group (P < 0.01) and from 16.2 ± 1.3 to 14.5 ± 1.7 mg/dL in the blue LED group (P < 0.01) after 24 h of phototherapy. No significant difference was found in TSB reduction after phototherapy between the groups.
Conclusions:
Both light sources produced a significant reduction in TSB, indicating clinical effectiveness.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1430803216	Green light-emitting spiro-copolymer		1430803-21-6	Price

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