Home
Resources
Publications
Guggulsterone Sensitizes Glioblastoma Cells to Sonic Hedgehog Inhibitor SANT-1 Induced Apoptosis in a Ras/NFκB Dependent Manner

Guggulsterone Sensitizes Glioblastoma Cells to Sonic Hedgehog Inhibitor SANT-1 Induced Apoptosis in a Ras/NFκB Dependent Manner

Deobrat Dixit, Ruchi Ghildiyal, Nikhil Ponnor Anto, Sourav Ghosh, Vivek Sharma, Ellora Sen

Cancer Lett. 2013 Aug 19;336(2):347-58.

PMID: 23548480

Abstract:

Since Shh pathway effector, Gli1, is overexpressed in gliomas, we investigated the effect of novel Shh inhibitor SANT-1 on glioma cell viability. Though SANT-1 failed to induce apoptosis, it reduced proliferation of glioma stem-like cells. Apart from canonical Shh cascade, Gli1 is also induced by non-canonical pathways including NFκB. Therefore, a combinatorial strategy with Ras/NFκB inhibitor, Guggulsterone, was employed to enhance effectiveness of SANT-1. Guggulsterone inhibited Ras and NFκB activity and sensitized cells to SANT-1 induced apoptosis via intrinsic apoptotic mechanism. Inhibition of either Ras or NFκB activity was sufficient to sensitize cells to SANT-1. Guggulsterone induced ERK activation also contributed to Caspase-9 activation. Since SANT-1 and Guggulsterone differentially target stem-like and non-stem glioma cells respectively, this combination warrants investigation as an effective anti-glioma therapy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP304909077	SANT-1		304909-07-7	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: