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H2-receptors in the Human Ocular Surface

H2-receptors in the Human Ocular Surface

M B Abelson, I J Udell

Arch Ophthalmol. 1981 Feb;99(2):302-4.

PMID: 6451212

Abstract:

Ten normal human volunteers participated in a two-part study of H2-receptor activity in the ocular surface. Dimethylaminopropylisothiourea (trivial name, dimaprit dihydrochloride), a highly selective H2-receptor agonist, produced vasodilation without itch. Pretreatment with the H2-receptor antagonist, cimetidine, significantly blocked the vasodilatory effect of dimethylaminopropylisothiourea, whereas pretreatment with the H1-receptor antagonist, antazoline phosphate, did not. We conclude that H2-receptors are present in the human ocular surface.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP23256339	Dimaprit dihydrochloride		23256-33-9	Price

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