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Harnessing the Biology of IL-7 for Therapeutic Application

Harnessing the Biology of IL-7 for Therapeutic Application

Crystal L Mackall, Terry J Fry, Ronald E Gress

Nat Rev Immunol. 2011 May;11(5):330-42.

PMID: 21508983

Abstract:

Interleukin-7 (IL-7) is required for T cell development and for maintaining and restoring homeostasis of mature T cells. IL-7 is a limiting resource under normal conditions, but it accumulates during lymphopaenia, leading to increased T cell proliferation. The administration of recombinant human IL-7 to normal or lymphopenic mice, non-human primates and humans results in widespread T cell proliferation, increased T cell numbers, modulation of peripheral T cell subsets and increased T cell receptor repertoire diversity. These effects raise the prospect that IL-7 could mediate therapeutic benefits in several clinical settings. This Review summarizes the biology of IL-7 and the results of its clinical use that are available so far to provide a perspective on the opportunities for clinical application of this cytokine.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248612	Interleukin-7 human			Price

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