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Heat Inactivation of the Middle East Respiratory Syndrome Coronavirus

India Leclercq, Christophe Batéjat, Ana M Burguière, Jean-Claude Manuguerra

Influenza Other Respir Viruses. 2014 Sep;8(5):585-6.

PMID: 25074677

Abstract:

The culture supernatants of the emerging Middle East respiratory syndrome coronavirus (MERS-CoV) were submitted to three temperatures over time and tested for infectivity by TCID50 method on Vero E6 cells. At 56°C, almost 25 minutes were necessary to reduce the initial titre by 4 log10 . Increasing temperature to 65°C had a strong negative effect on viral infectivity as virucidy dropped significantly to 1 minute. On the contrary, no significant decrease in titre was observed after 2 hours at 25°C. These data might be useful in establishing biosafety measures in laboratories against MERS-CoV.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP162640984 AT-56 AT-56 162640-98-4 Price
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