Home
Resources
Publications
Heating-induced Phase Transition of Bupropion Hydrobromide Polymorphs

Heating-induced Phase Transition of Bupropion Hydrobromide Polymorphs

Guoqing Zhang, Liping Gao, Zhaoxia Zhang, Lina Wang, Min Shao

J Pharm Sci. 2012 Sep;101(9):3091-5.

PMID: 22081455

Abstract:

Crystal phase transition and isothermal crystallization kinetics of bupropion hydrobromide is studied by thermal analysis, X-ray powder diffractometry, and scanning electron microscopy. As well known, bupropion hydrobromide has two stable polymorphic forms, form I and form II, during the production. Here it is found that form II will convert into form I with thermal treatment. Avrami exponent n is evaluated to be around 2.0 in the range 170°C-190°C, which indicates that the phase transition is a process of one-dimensional nucleation growth. This viewpoint is also confirmed by microscope morphology study. In addition, phase-transition active energy is calculated to be 239.4 kJ/mol, which means that a high energy barrier needs to be overcome to start up the phase transition.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP905818691	Bupropion hydrobromide		905818-69-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: