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Heparan Sulfate Proteoglycan (HSPG) Can Take Part in Cell Division: Inside and Outside

Heparan Sulfate Proteoglycan (HSPG) Can Take Part in Cell Division: Inside and Outside

Bettina Ughy, Ildiko Schmidthoffer, Laszlo Szilak

Cell Mol Life Sci. 2019 Mar;76(5):865-871.

PMID: 30465083

Abstract:

Prior to the cytokinesis, the cell-matrix interactions should be disrupted, and the mitotic cells round up. Prerequisite of mitosis, the centrosomes duplicate, spindle fibers are generated and move away from each other to opposite sides of the cells marking the cell poles. Later, an invagination in the plasma membrane is formed a few minutes after anaphase. This furrow ingression is driven by a contractile actomyosin ring, whose assembly is regulated by RhoA GTPase. At the completion of cytokinesis, the two daughter cells are still connected by a thin intercellular bridge, which is subjected to abscission, as the terminal step of cytokinesis. Here, it is overviewed, how syndecan-4, a transmembrane, heparan sulfate proteoglycan, can contribute to these processes in a phosphorylation-dependent manner.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4241166	Heparan sulfate proteoglycan			Price

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