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Hepatoprotective Effect of 2'-O-galloylhyperin Against Oxidative Stress-Induced Liver Damage Through Induction of Nrf2/ARE-mediated Antioxidant Pathway

Hepatoprotective Effect of 2'-O-galloylhyperin Against Oxidative Stress-Induced Liver Damage Through Induction of Nrf2/ARE-mediated Antioxidant Pathway

Peng Wang, Yi-Meng Gao, Xing Sun, Na Guo, Ji Li, Wei Wang, Li-Ping Yao, Yu-Jie Fu

Food Chem Toxicol. 2017 Apr;102:129-142.

PMID: 28213291

Abstract:

2'-O-galloylhyperin (2'-O-GH), an active compound isolated from Pyrola calliantha, possesses remarkable antioxidant activity. The aims of this study were to investigate the hepatoprotective effect of 2'-O-GH against oxidative stress and elucidate the underlying mechanistic signaling pathways in HepG2 cells as well as in an animal model. Results showed that 2'-O-GH significantly inhibited hydrogen peroxide (H2O2)-induced HepG2 cell death in a dose dependent manner. The mitogen-activated protein kinase activation, ROS production, mitochondrial membrane potential, intracellular calcium level and subsequent apoptotic protein activation in H2O2-stimulated HepG2 cells were remarkably inhibited by 2'-O-GH. Furthermore, 2'-O-GH stimulation resulted in a fast and dramatic activation of Akt and nuclear translocation of the NF-E2-related factor 2 (Nrf2), along with the increased expression of heme oxygenase-1 (HO-1) and levels of glutathione (GSH). Meanwhile, histopathological evaluation of the liver also revealed that 2'-O-GH effectively ameliorated CCl4-induced the hepatic damage by reducing alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. Therefore, these results suggested the hepatoprotective effect of 2'-O-GH might be correlated with its antioxidant and free radical scavenger effect.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP53209271	2′′-Galloylhyperin		53209-27-1	Price

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