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Hepatoprotective Effect of Manganese Chloride Against CCl4-induced Liver Injury in Rats

Hepatoprotective Effect of Manganese Chloride Against CCl4-induced Liver Injury in Rats

Akram Eidi, Pejman Mortazavi, Khodabakhsh Behzadi, Ali Haeri Rohani, Shahabeddin Safi

Biol Trace Elem Res. 2013 Nov;155(2):267-75.

PMID: 24037643

Abstract:

The aim of the present study is to evaluate the protective effect of manganese chloride against carbon tetrachloride (CCl4)-induced liver injury in rats. Manganese chloride (0.001, 0.01, 0.05 and 0.1 g/kg bw) was administered intragastrically for 28 consecutive days to male CCl4-treated rats. The hepatoprotective activity was assessed using various biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ-glutamyltransferase (GGT) and superoxide dismutase (SOD). Histopathological changes in the liver of different groups were also studied. Administration of CCl4 increased the serum ALT, AST, ALP and GGT but decreased SOD levels in rats. Treatment with manganese chloride significantly attenuated these changes to nearly normal levels. The animals treated with manganese chloride have shown decreased necrotic zones and hepatocellular degeneration when compared to the liver exposed to CCl4 intoxication alone. Thus, the histopathological studies also supported the protective effect of manganese chloride. Therefore, the results of this study suggest that manganese chloride exerts hepatoprotection via promoting antioxidative properties against CCl4-induced oxidative liver damage.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP13446349-A	Manganese chloride		13446-34-9	Price

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