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Hepatoprotective Efficacy of Premna Integrifolia L. Leaves Against Aflatoxin B1-induced Toxicity in Mice

Hepatoprotective Efficacy of Premna Integrifolia L. Leaves Against Aflatoxin B1-induced Toxicity in Mice

Chandrashekhar Singh, Chandra Prakash, Pallavi Mishra, Kavindra Nath Tiwari, Sunil Kumar Mishra, Raghunath Shahaji More, Vijay Kumar, Jasmeet Singh

Toxicon. 2019 Aug;166:88-100.

PMID: 31125618

Abstract:

The present study evaluated the hepatoprotective role of ethanol extract of P. integrifolia leaves (EEPL) on aflatoxin B1 (AFB1)-induced toxicity in mice. Mice were administered with AFB1 (0.1 mg/kg b. wt., orally) for 90 days, EEPL (400 and 600 mg/kg b. wt., orally) and silymarin (100 mg/kg b. wt., orally) in combination with AFB1. The study shows the protective effect of EEPL by the restoration of altered hematological indices and liver marker enzymes. Restoration of lipid peroxidation and glutathione content, along with activities of antioxidant enzymes, suggest amelioration of oxidative stress in AFB1-intoxicated mice. In addition, EEPL attenuated apoptosis and histopathological alterations in liver tissue. In conclusion, the current study suggests that EEPL protect mice liver against AFB1 toxicity by inhibiting oxidative stress and apoptosis. The protective activity of EEPL may be due to the enrichment of flavonoids (neohesperidin, apigenin-7-O-glucoside, catechin hydrate, cyanidin chloride, quercetin-3-galactoside, diosmin, genistein, malvin chloride, 4-hydroxy-3-methoxycinnamic acid, kaempferol-3-O-alpha-L-arabinoside, myricitrin, poncirin, vitexin and tiliroside) in the extract as identified by UPLC-QTOF-MS/MS.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP111613048-B	Cyanidin 3-O-α-L-arabinoside chloride		111613-04-8	Price
AP16727303-A	Malvin(chloride)		16727-30-3	Price

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