Home
Resources
Publications
Heptakis(2,6-di-O-methyl)-beta-cyclodextrin Complexation With the Antitumor Agent Chlorambucil

Heptakis(2,6-di-O-methyl)-beta-cyclodextrin Complexation With the Antitumor Agent Chlorambucil

A R Green, J K Guillory

J Pharm Sci. 1989 May;78(5):427-31.

PMID: 2746481

Abstract:

The effects of heptakis(2,6-di-O-methyl)-beta-cyclodextrin (DIMEB) and of beta-cyclodextrin (beta-CD) on the aqueous solubility and stability of chlorambucil (CHL) have been compared. In the presence of 1.3 x 10(-3) M DIMEB, there is a greater than 20-fold increase in the stability of chlorambucil at 37 degrees C, pH 4.13. Aqueous solubility of CHL is increased more than 40-fold in the presence of 1.74 x 10(-2) M DIMEB when the solubility is studied under conditions where degradation is minimized (3.0 degrees C, pH 4.13). In the presence of 1.3 x 10(-3) M beta-CD, there is a fourfold increase in the stability, and with 1.74 x 10(-2) M beta-CD, there is a threefold increase in the aqueous solubility of CHL under similar conditions. Stability constants of the CHL complex with DIMEB were determined kinetically and spectrophotometrically under various experimental conditions assuming 1:1 inclusion complex formation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP51166713	Heptakis(2,6-di-O-methyl)-β-cyclodextrin		51166-71-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: