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Heptakis(2-O-methyl-3,6-di-O-sulfo)-beta-cyclodextrin: A Single Isomer, 14-sulfated Beta-Cyclodextrin for Use as a Chiral Resolving Agent in Capillary Electrophoresis

Heptakis(2-O-methyl-3,6-di-O-sulfo)-beta-cyclodextrin: A Single Isomer, 14-sulfated Beta-Cyclodextrin for Use as a Chiral Resolving Agent in Capillary Electrophoresis

D K Maynard, G Vigh

Electrophoresis. 2001 Sep;22(15):3152-62.

PMID: 11589274

Abstract:

The first single-isomer, 14-sulfated beta-cyclodextrin, the sodium salt of heptakis(2-O-methyl-3,6-di-O-sulfo)-beta-cyclodextrin (HMdiSu) has been used to separate 24 pharmaceutical weak base enantiomers in pH 2.5 background electrolytes using capillary electrophoresis. For the weakly binding bases, the cationic effective mobilities decreased, approached zero, and then increased again. For the strongly binding bases, the cationic effective mobilities decreased, became anionic at very low concentrations of HMdiSu, passed an anionic mobility maximum, then decreased again as the HMdiSu concentration was increased. Viscosity corrections according to Walden's rule did not eliminate these unexpected effective mobility extrema. The mobility extrema were rationalized by extending the charged resolving agent migration model (CHARM model) to include ionic strength effects.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP37191698	β-Cyclodextrin, sulfated sodium salt		37191-69-8	Price

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