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Herpes Simplex Virus Type 2 Latency in the Footpad of Mice: Effect of Acycloguanosine on the Recovery of Virus

Herpes Simplex Virus Type 2 Latency in the Footpad of Mice: Effect of Acycloguanosine on the Recovery of Virus

S A Al-Saadi, P Gross, P Wildy

J Gen Virol. 1988 Feb;69 ( Pt 2):433-8.

PMID: 2828517

Abstract:

Herpes simplex virus type 2 has been reactivated from the latent state in the footpad and dorsal root ganglia of acycloguanosine-treated BALB/c mice. Virus was also recovered from the footpad tissue but not from the ganglia of denervated, latently infected mice. Treatment in vitro of explanted footpad cultures with acycloguanosine or phosphonoacetic acid did not affect the rate of virus reactivation. In all the isolates examined the virus was found to be acycloguanosine-sensitive. Recovery of virus from footpad tissue of mice after a long period of acycloguanosine treatment supports the theory that virus had been truly latent in the footpad and not in a state of persistent infection.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP59277893-A	Acycloguanosine		59277-89-3	Price

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