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Heterobiaryl and Heterobiaryl Ether Derived M5 Positive Allosteric Modulators

Thomas M Bridges, J Phillip Kennedy, Corey R Hopkins, P Jeffrey Conn, Craig W Lindsley

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5617-22.

PMID: 20801651

Abstract:

This Letter describes a chemical lead optimization campaign directed at VU0238429, the first M(5)-preferring positive allosteric modulator (PAM), discovered through analog work around VU0119498, a pan G(q) mAChR M(1), M(3), M(5) PAM. An iterative parallel synthesis approach was employed to incorporate basic heterocycles to improve physiochemical properties.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1160247926 VU0238429 VU0238429 1160247-92-6 Price
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