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Heterogeneous Effects of Cholecystokinin on Neuronal Response Properties in Deep Layers of Rat Barrel Cortex

Heterogeneous Effects of Cholecystokinin on Neuronal Response Properties in Deep Layers of Rat Barrel Cortex

Narjes Soltani, Ali Roohbakhsh, Mohammad Allahtavakoli, Elham Salari, Vahid Sheibani, Iman Fatemi, Ali Shamsizadeh

Somatosens Mot Res. 2018 Jun;35(2):131-138.

PMID: 30105939

Abstract:

Cholecystokinin (CCK) is one of the most studied neuropeptides in the brain. In this study, we investigated the effects of CCK-8s and LY225910 (CCK2 receptor antagonist) on properties of neuronal response to natural stimuli (whisker deflection) in deep layers of rat barrel cortex. This study was done on 20 male Wistar rats, weighing 230-260 g. CCK-8s (300 nmol/rat) and LY225910 (1 µmol/rat) were administered intracerebroventricularly (ICV). Neuronal responses to deflection of principal (PW) and adjacent (AW) whiskers were recorded in the barrel cortex using tungsten microelectrodes. Computer controlled mechanical displacement was used to deflect whiskers individually or in combination at 30 ms inter-stimulus intervals. ON and OFF responses for PW and AW deflections were measured. A condition-test ratio (CTR) was computed to quantify neuronal responses to whisker interaction. ICV administration of CCK-8s and LY225910 had heterogeneous effects on neuronal spontaneous activity, ON and OFF responses to PW and/or AW deflections, and CTR for both ON and OFF responses. The results of this study demonstrated that CCK-8s can modulate neuronal response properties in deep layers of rat barrel cortex probably via CCK2 receptors.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP133040774	LY225910		133040-77-4	Price

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